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Cardiac stem cells from young hearts could rejuvenate old hearts

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Telomeres, stained in purple, are caps which shield our chromosomes from harm. They get shorter with growing old and are enlarged with younger CDCs within the research. Credit score: Cedars-Sinai Cardiac stem cell infusions might sometime assist reverse the growing old course of within the human coronary heart, making older ones behave youthful, in response to a brand new research from the Cedars-Sinai Coronary heart Institute. "Our earlier lab research and human scientific trials have proven promise in treating coronary heart failure utilizing cardiac stem cell infusions," stated Eduardo Marbán, MD, PhD, director of the Cedars-Sinai Coronary heart Institute and the first investigator of the research. "Now we discover that these specialised stem cells might end up to reverse issues related to growing old of the center." The research was revealed in the present day by the  European Coronary...

New way to activate stem cells to make hair grow

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  Untreated mouse pores and skin exhibiting no hair development (left) in comparison with mouse pores and skin handled with the drug UK5099 (proper) exhibiting hair development. Credit score: UCLA Broad Stem Cell Middle/Nature Cell Biology UCLA researchers have found a brand new strategy to activate the stem cells within the hair follicle to make hair develop. The analysis, led by scientists Heather Christofk and William Lowry, might result in new medicine that might promote hair development for folks with baldness or alopecia, which is hair loss related to such components as hormonal imbalance, stress, getting older or chemotherapy therapy. The analysis was printed within the journal  Nature Cell Biology . Hair follicle stem cells are long-lived cells within the hair follicle; they're current within the pores and skin and produce hair all through an individual's lifetime. They're "quiescent...

How a nutrient, glutamine, can control gene programs in cells

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs have to be turned on or off. Revealing the intricate ways this is done is one of the great goals of biomedical research, especially because dysregulation of gene programs underlies diseases like cancer and those caused by destructive inflammation. While some general influences of cellular metabolism on gene control are known -- such as the fact that glutamine metabolism by embryonic stem cells influences differentiation and causes some epigenetic changes in the DNA, as well as in the proteins that compact or unravel genomic DNA -- a major gap in current knowledge is how such broad epigenetic events are precisely translated into specific differentiation gene programs. A research team, led by first author and University of Alabama at Birmingham graduate student Danielle Chisolm and...